Example Projects

2014

3D Printing of Bacteria
Applications of cell-cell communication to Synthetic Biology
Bioengineering red blood cells using gene editing techniques
Coiled-coil directed photosynthetic protein self-assemblies and programmable nano-reactor systems
Communication between live and synthetic cells
Communication between natural bacteria and artificial protocells
Controlling extrinsic noise in mammailiancells
Creating Logic-Gated Synthetic Antibodies to bring Boolean Protein to Medicine
Designed components for transcriptional control in cells
Development of SimCells as building blocks for synthetic blocks for synthetic biology
DNA-Templated assembly of dynamic α-helical peptide barrels
DNA-Templated Assembly of the Bacterial Flagellar Motor’s Torque-Generating Ring
Electronic interface to control cell and community metabolism
Embedded Cellular Controls
Engineering a synthetic phage
Engineering Logic gates in bacteria using two-component signalling
Engineering non-replicative bacteriophage-based payload systems for pathogen elimination.
Engineering Switches for Plant Growth Promotion in the Rhizosphere
Gene Regulatory Networks: components and control
Inducing Recombination in Plants Using Genome Editing Techniques
In-silico design of synthetic gene regularory networks for feedback control system implementation
Investigation of in vitro protein reconstruction directionality control
Light-activated gene expression for inducible communication in aqueous droplet networks
Measuring Molecules:Developing a Nanometre-Scale Ruler Using FRET
Modelling Gene Expression in a Homogenous Bacterial Population
Orthogonal Transcription Factors using Designed TALEs and Coliled Coils
Resource allocation in synthetic gene networks
Re-wiring plant signalling pathways to enhance stress tolerance
Simulation of Microbial Community in a microfluidic device
Synthetic Microbial Communities
Synthetic Metabolons
Synthetically Regulated Nitrogen Fixing in Association with Cereals
The de novo design of coiled-coil-based transcriptional regulators
Using in silico approaches to design evolutionarily robust network topologies

2015

Development of reporter strains for bacterial electro-physiology
3D Printing of Living Cells using Droplet Networks
3D Printing of Living Cells using Droplet Networks
Accelerated directed evolution of proteins using phages
Active DNA Nanosystems in non aqueous solvents
Adaptive Genetic Logic Gates
Analogue gates for control applications
Artificial Ribosomes - programmable chemical synthesis using DNA templates
Characterising the binding properties of RNA aptamers to short peptides
Construction and Laboratory evolution of artificial oxidoreductases
Continuous Directed Evolution in MFC System
Control of Cell Population and Synthetic Communities
Design and construction of active DNA-templates for alpha-helical barrels.
Designing SimCells from Cyanobacteria for the Production of Molecular Oxygen
Developing glycan-functionalised carbon nanodots to investigate cell type signalling during root nodulation.
Development of an integrated synthetic biology/chemical engineering design pipeline
Directed Evolution in Non-Living Systems
Directed evolution of artificial peroxidases
Dissecting noise in gene expression systems for synthetic biology
Engineering a synthetic gut model to explore gut microbial interactions/ Synthetic Communities
Engineering new DNA recognition elements using the DsdS subunit from type I restriction endonucleases
Engineering re-writable memory in T cells for immunotherapy
Evaluating the biocatalyst potential of a novel enzyme
Formulation and testing of Synthetic Vaccines
Improving gene therapy efficiency: linking Cas-9 and homologous recombination.
In silico simulation and analysis of gene expression variance between individual cells of a homogenous population.
In vitro chemical ligation of modified DNA
Intracellular Selex to study Stress -Related Translation
Investigating noise in gene expression using single molecule tracking
Membrane-inserting SpyCatcher for virus-like particle vaccines
Office adjacent to M116, School of Life Sciences.
On the development of synthetic cartilage
Re-engineering a natural Diels-Alderase for the production of new antibiotics
RNA-Inducible CRISPR-Cas9 transcription regulators
simCell Toluene Biosensor
Spatial organisation of enzymes using virus -like particles (VLP)
Synthetic Enzyme Assemblies
Systematic analysis of the ability of protein transduction domains to export cargo proteins from cells, and to deliver them into adjacent cells
Utilisation of Membrane Voltage for Synthetic Biology Genetic Circuits

2016

3D Bioprinted Self-Polymerising Bacterial Bioreactors
CRISPR/dCas9 Synergistic Activation Mediators (SAM) as a tool for modulating gene expression in human induced pluripotent stem cells (hiPS)
Design and Evaluation of novel Diels-Alderases for use in Industry
Developing 3D Vascularized Tissues through Inputted Microchanel Flow
Developing synthetic biology tools to engineer the production of valuable compounds in the alga Euglena gracillis
Development of Biosensors for diagnosis and drug delivery in the human gut
Engineering Antibiotics from Abyss
Engineering Genetic Amplifiers
Engineering multistability in microbial physiology
Engineering new microbial rhodopsins for novel 21sat century sensor
Engineering receptors for optimised T cell dose responses
Feedback design and modelling using Srna
Heterologous expression and engineering of an industrially important macrolide biosynthetic pathway
Impact of cellular trade-offs on synthetic genetic circuits across cell populations
In vitro prototyping of modular polyketide synthases
Investigations into 3D Printed Dropet Networks
Learning and verifying uncertain models of Chemical Reaction
Molecular simulations and the Design of Gated Nanopores
Network to network interaction
Packing in 3D printed droplet networks
Protein Design in the cell: towards synthetic proteomes
Study of link between bacterial competition and diversity using 3D bacterial printing technology
SynBac: Synthetic Baculovirus for Next-Generation Gene Therapy
Synthetic Tissues from printed droplet networks
Towards a Comprehensive Theory of Feedback Control from Chemical Reaction Networks
Towards Overcoming Antimicrobial Resistance using Synthetic Biology
Turning immune cell reactivity using synthetic receptors

2017

Molecules and Origins of Life
Rotary Molecular Motors
Synthetic Tissues from printed droplets networks
Gentically engineering machines for intelligent cell stimulation and early warning
Engineering new microbial rhodopsins for novel 21st century sensor materials for broad- banded , molecular scale wavelength selective detectopm/ Synthetic Biology
Synthetic reconstitution of mitotic switch
Development of encapsulated biosensors for diagnosis and drug delivery in human gut
DNA Nanostructures
Towards Overcoming Antimicrobial Resistance Using Synthetic Biology/ Schofield Group Research
Developing Synthetic Biology tools to engineer the production of valuable compound in the alga Euglena gracillis
Engineering gentic amplifiers for the detection of carcingogens in human gut
Molecular Simulation and Design of Gated Nanopores
Re-engineering photosynthesis for improved crop yield
Development of SimCells as smart bioparticles under control of aspirin
The design of DNA nanostructures using computational techniques
Microbial Social Evolution
Shaping the steady-state behaviour of a biological model
Feedback design and modeling using post-transcriptional regulation
Network-to Nework interaction
Understanding and engineering microbial communities
Precise reduction of models of chemical reaction networks
Real Time Broadcast control of gene expression of a population of cells
Rewiring T cells for dose discrimination using synthetic receptors